Anti-Heat shock factor proteïne 2 HSF2 Antilichaam Picoband® fluoro488 Vervoeging

HSF2 (HEAT-SHOCK TRANSCRIPTION FACTOR 2), also called HEAT-SHOCK FACTOR 2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. The International Radiation Hybrid Mapping Consortium maps the HSF2 gene to chromosome 6. Mouse Hsf2 was expressed in all 3 embryonic layers at embryonic day 7.5 and that the head fold was strongly stained at embryonic day 8.5. In adults, Hsf2 expression is detected in spermatocytes and spermatogonia, but not in elongated spermatids, spermatozoa, or Sertoli cells. Hsp70i bookmarking is mediated by a transcription factor called HSF2, which binds this promoter in mitotic cells, recruits protein phosphatase-2A, and interacts with the CAPG subunit of the condensin enzyme to promote efficient dephosphorylation and inactivation of condensin complexes in the vicinity, thereby preventing compaction at this site. And Hsf2-null mice were born at the expected mendelian ratio but had brain abnormalities and meiotic and gametogenic defects in both genders.

Heat shock factor protein 2; HSF 2; Heat shock transcription factor 2; HSTF 2; HSF2; HSTF2

HSF2

3298

Q03933

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human HSF2, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

Embryonic nervous system.

Flow Cytometry

Epigenetics and Nuclear Signaling, Transcription

Immunogen affinity purified.

Liquid

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

1. Schuetz, T. J. Personal Communication. Boston, Mass. 10/3/1991 2. Schuetz, T. J., Gallo, G. J., Sheldon, L., Tempst, P., Kingston, R. E. Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. Proc. Nat. Acad. Sci. 88: 6911-6915, 1991.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

60348 MW

No cross reactivity with other proteins.

6

Heat shock factor protein 2

Cytoplasm . Nucleus . Cytoplasmic during normal growth and moves to the nucleus upon activation.

Belongs to the HSF family.

Heat shock factor protein 2 (HSF 2)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.