Anti-Hfe Antibody Picoband® fluoro488 Vervoeging

Human homeostatic iron regulator protein, also known as the HFE protein (High FE2+), is a protein which in humans is encoded by the HFE gene. Enables transferrin receptor binding activity. Involved in positive regulation of gene expression. Acts upstream of or within hormone biosynthetic process and multicellular organismal iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in brain; choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; and metencephalon part of 4th ventricle choroid plexus. Used to study hemochromatosis type 1. Human ortholog (s) of this gene implicated in several diseases, including acute porphyria (multiple) ; arthritis (multiple) ; bone marrow cancer (multiple) ; hemochromatosis (multiple) ; and liver disease (multiple) . Orthologous to human HFE (homeostatic iron regulator) .

Hereditary hemochromatosis protein; HLA-H; HFE; HLAH

Hfe

15216

P70387

Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived mouse Hfe recombinant protein (Position: N112-H227) .

Expressed in all tissues tested except brain.

Flow Cytometry

Cofactors, Vitamins/Minerals, Hematopoietic Progenitors, Metabolism, Myeloid, Pathways and Processes, Signal Transduction, Stem Cells, Vitamins/Minerals

Immunogen affinity purified.

Liquid

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. .

1. Aguilar-Martinez, P., Bismuth, M., Picot, M. C., Thelcide, C., Pageaux, G.-P., Blanc, F., Blanc, P., Schved, J.-F., Larrey, D. Variable phenotypic presentation of iron overload in H63D homozygotes: are genetic modifiers the cause? Gut 48: 836-842, 2001. 2. Allen, K. J., Gurrin, L. C., Constantine, C. C., Osborne, N. J., Delatycki, M. B., Nicoll, A. J., McLaren, C. E., Bahlo, M., Nisselle, A. E., Vulpe, C. D., Anderson, G. J., Southey, M. C., Giles, G. G., English, D. R., Hopper, J. L., Olynyk, J. K., Powell, L. W., Gertig, D. M. Iron-overload-related disease in HFE hereditary hemochromatosis. New Eng. J. Med. 358: 221-230, 2008. 3. Andersen, R. V., Tybjaerg-Hansen, A., Appleyard, M., Birgens, H., Nordestgaard, B. G. Hemochromatosis mutations in the general population: iron overload progression rate. Blood 103: 2914-2919, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

40108 MW

6

Hereditary hemochromatosis protein

Cell membrane ; Single-pass type I membrane protein .

Hereditary hemochromatosis protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.