Anti-HIF-2 alpha EPES1 Konijn Monoklonale Antilichaam

Boster Bio Anti-HIF-2 alpha EPAS1 Rabbit Monoclonal Antibody catalog # M01248. Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Endothelial PAS domain-containing protein 1; EPAS-1; Basic-helix-loop-helix-PAS protein MOP2; Class E basic helix-loop-helix protein 73; bHLHe73; HIF-1-alpha-like factor; HLF; Hypoxia-inducible factor 2-alpha; HIF-2-alpha; HIF2-alpha; Member of PAS protein 2; PAS domain-containing protein 2; EPAS1; BHLHE73, HIF2A, MOP2, PASD2

EPAS1

2034

Q99814

Human, Mouse, Rat

A synthesized peptide derived from human HIF-2 alpha

Clone: ADD-5

Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.

WB, ICC, IF, Flow Cytometry

Cancer, Cancer Metabolism, Cardiovascular,2339, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Hypoxia, Invasion/Microenvironment, Metabolic Signaling Pathways, Metabolism, Metabolism Processes, Nucleotide Metabolism, Pathways and Processes, Response To Hypoxia, Transcription

Affinity-chromatography

0.5mg/ml

Liquid

Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M01248

96459 MW

80 kDa

Endothelial PAS domain-containing protein 1

Nucleus . Nucleus speckle . Colocalizes with HIF3A in the nucleus and speckles. .

Glycogen synthase kinase-3 beta (gsk3b)

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5 mg/ml BSA.