Anti-Hikeshi Antilichaam

This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress.

Boster Bio Anti-Hikeshi Antibody catalog # A31868-1. Tested in WB, IHC, IP, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Hikeshi

Q53FT3

Human, Mouse, Rat

E.coli-derived human Hikeshi recombinant protein (Position: 3-190) .

WB, IHC, IP, ELISA

Immunogen affinity purified.

500 μg/mL

Liquid

12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A31868-1

500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.