Anti-HIP2/LIG/UBE2K Antibody Picoband® fluoro550 Vervoeging

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.

Troponin T, fast skeletal muscle; TnTf; Beta-TnTF; Fast skeletal muscle troponin T; fTnT; TNNT3

UBE2K

3093

P61086

Human, Mouse, Rat, Monkey

No cross-reactivity with other proteins.

E.coli-derived human HIP2/LIG/UBE2K recombinant protein (Position: D33-E195) .

In fetal and adult fast skeletal muscles, with a higher level expression in fetal than in adult muscle.

Flow Cytometry

Golgi Proteins, Organelles, Protein Trafficking, Signal Transduction, Subcellular Markers

Immunogen affinity purified.

Liquid

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

1. Kalchman, M. A., Graham, R. K., Xia, G., Koide, H. B., Hodgson, J. G., Graham, K. C., Goldberg, Y. P., Gietz, R. D., Pickart, C. M., Hayden, M. R. Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. J. Biol. Chem. 271: 19385-19394, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Troponin T3, fast skeletal type

Troponin complex. Cytosol.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.