Anti-histone H1,0/H1F0 Antibody Picoband® (monoklonaal, 5I3E6)

H1 histone family, member 0is a member of thehistonefamily of nuclearproteinswhich are a component ofchromatin. In humans, this protein is encoded by theH1F0gene. It is mapped to 22q13.1. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family.

T-complex protein 1 subunit gamma; TCP-1-gamma; CCT-gamma; hTRiC5; CCT3; CCTG; TRIC5

H1F0

3005

P07305

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human Histone H1.0/H1F0 recombinant protein (Position: K20-K159) .

Clone: 5I3E6

Ubiquitously expressed with highest levels in spleen, thymus and immature brain.

Flow Cytometry

Chaperones, Protein Trafficking, Signal Transduction

Immunogen affinity purified.

Liquid

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

1. Doenecke D, Tönjes R (February 1986) . Differential distribution of lysine and arginine residues in the closely related histones H1 and H5. Analysis of a human H1 gene. Journal of Molecular Biology. 187 (3) : 461–4. 2. Albig W, Drabent B, Kunz J, Kalff-Suske M, Grzeschik KH, Doenecke D (June 1993) . All known human H1 histone genes except the H1 (0) gene are clustered on chromosome 6. Genomics. 16 (3) : 649–54.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Chaperonin containing TCP1 subunit 3

Cytoplasm.

Mouse IgG2b

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.