Anti-Histone H2A.X H2AFX Konijn Monoklonale Antilichaam

Boster Bio Anti-Histone H2A.X H2AFX Rabbit Monoclonal Antibody catalog # M00241-1. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

Histone H2AX; H2a/x; Histone H2A.X; H2AFX; H2AX

H2AFX

3014

P16104

Human, Mouse, Rat

A synthesized peptide derived from human Histone H2A.X

Clone: BIA-8

Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.

WB, IHC, ICC, IF, IP

2339, DNA/RNA, DNA Damage Response, Epigenetics and Nuclear Signaling, Histones

Affinity-chromatography

0.5mg/ml

Liquid

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00241-1

15145 MW

100-110 kDa

Histone H2AX

Nucleus . Chromosome .

P2X purinoceptor 1

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.