Anti-histone H3,3 H3F3A Konijn Monoklonale Antilichaam

Boster Bio Anti-Histone H3.3 H3F3A Rabbit Monoclonal Antibody catalog # M06819. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Histone H3.3; H3F3A; H3.3A, H3F3; PP781; H3F3B; H3.3B

H3F3A

3020

P84243

Human, Mouse, Rat

A synthesized peptide derived from human Histone H3.3

Clone: EBF-8

Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level) . Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate. .

WB, IHC, ICC, IF

2339, Epigenetics and Nuclear Signaling, Histones

Affinity-chromatography

0.5mg/ml

Liquid

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M06819

15328 MW

94 kDa

Histone H3.3

Nucleus. Chromosome.

T-cell surface glycoprotein CD3 zeta chain

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.