Anti-HNF1 beta/HNF1B Antibody Picoband® fluoro550 Vervoeging

HNF1 homeobox B (hepatocyte nuclear factor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene. It is a member of the homeodomain-containing superfamily of transcription factors. This gene is mapped to 17q12. The HNF1B protein is believed to form heterodimers with another liver-specific member of this transcription factor family, TCF1. HNF1B functions as both a classic transcriptional activator and as a bookmarking factor that marks target genes for rapid transcriptional reactivation after mitosis. HNF1B also can regulate renal tubulogenesis by controlling expression of SOC3. Mutation of HNF1B that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5) .

Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; Homeoprotein LFB3; Transcription factor 2; TCF-2; Variant hepatic nuclear factor 1; vHNF1; HNF1B; TCF2

HNF1B

6928

P35680

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human HNF1 beta, identical to the related mouse and rat sequences.

Highest expression in brain, lower in heart, kidney, pancreas, placenta, lung and skeletal muscle.

Flow Cytometry

Diabetes, Epigenetics and Nuclear Signaling, Metabolism, Transcription

Immunogen affinity purified.

Liquid

Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.

1. Bach, I., Mattei, M.-G., Cereghini, S., Yaniv, M. Two members of an HNF1 homeoprotein family are expressed in human liver. Nucleic Acids Res. 19: 3553-3559, 1991. 2. Entrez Gene: TCF2 transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor 3. Verdeguer, F., Le Corre, S., Fischer, E., Callens, C., Garbay, S., Doyen, A., Igarashi, P., Terzi, F., Pontoglio, M. A mitotic transcriptional switch in polycystic kidney disease. (Letter) Nature Med. 16: 106-110, 2010.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

61324 MW

No cross reactivity with other proteins.

6

Hepatocyte nuclear factor 1-beta

Nucleus.

Belongs to the HNF1 homeobox family.

Hepatocyte nuclear factor 1-beta

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.