Anti-hnRNP U/p120/HRNPU Antilichaam Picoband®

Heterogeneous nuclear ribonucleoprotein U is a protein that in humans is encoded by the HNRNPU gene. This gene encodes a member of a family of proteins that bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA) . The encoded protein has affinity for both RNA and DNA, and binds scaffold-attached region (SAR) DNA. Mutations in this gene have been associated with epileptic encephalopathy, early infantile, 54. A pseudogene of this gene has been identified on chromosome 14.

Boster Bio Anti-hnRNP U/p120/HNRNPU Antibody Picoband® catalog # A03691-3. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

P-selectin glycoprotein ligand; Selplg; Psgl1

HNRNPU

3192

Q00839

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human hnRNP U/p120/HNRNPU recombinant protein (Position: E262-L563) .

Highly expressed in blood, bone marrow, brain, adipose tissue, spleen, and thymus. Also expressed in heart, kidney, liver, muscle, ovary, and stomach.

ELISA, Flow Cytometry, IF, IHC, ICC, WB

Cardiovascular, Cell Biology, Platelets, Protease Inhibitors, Proteolysis/Ubiquitin, Proteolytic Enzymes

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

A SLe (x) -type proteoglycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.

1. Carvill, G. L., Heavin, S. B., Yendle, S. C., McMahon, J. M., O'Roak, B. J., Cook, J., Khan, A., Dorschner, M. O., Weaver, M., Calvert, S., Malone, S., Wallace, G., and 22 others. Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1. Nature Genet. 45: 825-830, 2013. 2. de Kovel, C. G. F., Brilstra, E. H., van Kempen, M. J. A., van't Slot, R., Nijman, I. J., Afawi, Z., De Jonghe, P., Djemie, T., Guerrini, R., Hardies, K., Helbig, I., Hendrickx, R., and 13 others. Targeted sequencing of 351 candidate genes for epileptic encephalopathy in a large cohort of patients. Molec. Genet. Genomic Med. 4: 568-580, 2016. 3. Epi4K Consortium and Epilepsy Phenome/Genome Project. De novo mutations in epileptic encephalopathies. Nature 501: 217-221, 2013.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A03691-3

28461 MW

120 kDa

6

Selectin P ligand

Integral component of membrane.

Breast cancer metastasis-suppressor 1

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.