Anti-HOXC12 Antibody Picoband® fluoro488 Vervoeging

Homeobox C12 is a protein that in humans is encoded by the HOXC12 gene. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

HOXC12

3228

P31275

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human HOXC12 recombinant protein (Position: M1-N195) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Kang, X. , Qi, Y. , Yong, Z. , Qi, W. , & Yeh, E. . (2010) . Sumo-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Molecular Cell, 38 (2), 191-201. 2. Grier, D. G. , Thompson, A. , Lappin, T. , & Halliday, H. L. . (2009) . Quantification of hox and surfactant protein-b transcription during murine lung development. Neonatology, 96 (1), 50-60. 3. Katayama, K. , Furuno, A. , Akiyama, K. , Tsuji, T. , & Kunieda, T. . (2007) . Characterization of chromosomal inversion of the mouse hairy ears (eh) mutation associated with cleft palate. Mammalian Genome, 18 (4), 246-254.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.