Anti-Hrk-antilichaam

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3) -only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.

Boster Bio Anti-Hrk Antibody (Catalog # A09125) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

DP5, HARAKIRI, BID3, Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3

HRK

O00198

Human, Mouse

HRK antibody was raised against a 15 amino acid synthetic peptide from near the center of human Hrk. The immunogen is located within the last 50 amino acids of Hrk.

Ubiquitously expressed.

ELISA, WB

Signal Transduction, Neuroscience

Hrk Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Promotes apoptosis.

Hrk antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A09125

9884 MW

Harakiri, BCL2 interacting protein (contains only BH3 domain)

Membrane; Single-pass membrane protein. Mitochondrion.

Harakiri, BCL2 interacting protein (contains only BH3 domain)

IgG

Hrk Antibody is supplied in PBS containing 0.02% sodium azide.