Anti-HSD11B1 Antibody Picoband® fluoro488 Vervoeging

11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. Tannin et al. (1991) localized the HSD11B1 gene to chromosome 1. The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe. Schutte et al. (2000) mapped the HSD11B1 gene to 1q32-q41.

Corticosteroid 11-beta-dehydrogenase isozyme 1;1.1.1.146;11-beta-hydroxysteroid dehydrogenase 1;11-DH;11-beta-HSD1; Short chain dehydrogenase/reductase family 26C member 1; HSD11B1; HSD11, HSD11L, SDR26C1

HSD11B1

3290

P28845

Human, Monkey, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human HSD11B1, different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.

Widely expressed. Highest expression in liver.

Flow Cytometry

Endocrine Metabolism, Hormone Biosynthesis, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one ion, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity) . .

1. Entrez Gene: HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

32401 MW

No cross reactivity with other proteins.

6

Corticosteroid 11-beta-dehydrogenase isozyme 1

Endoplasmic reticulum membrane ; Single-pass type II membrane protein .

Belongs to the connexin family. Beta-type (group I) subfamily.

Corticosteroid 11-beta-dehydrogenase isozyme 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.