Anti-HSD11B1 Antibody Picoband® fluoro594 Vervoeging

11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. Tannin et al. (1991) localized the HSD11B1 gene to chromosome 1. The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe. Schutte et al. (2000) mapped the HSD11B1 gene to 1q32-q41.

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; MAD3/BUB1-related protein kinase; Hbubr1; Mitotic checkpoint kinase MAD3L; Protein SSK1; BUB1B; BUBR1, MAD3L, SSK1

HSD11B1

3290

P28845

Human

No cross-reactivity with other proteins.

E.coli-derived human HSD11B1 recombinant protein (Position: E30-K292) .

Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.

Flow Cytometry

Apoptosis, Associated Proteins, Calcium Channels, Calcium Signaling, Cell Biology, Intracellular, Neuroscience, Neurotransmission, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.

1. Entrez Gene: HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

BUB1 mitotic checkpoint serine/threonine kinase B

Membrane; Colocalizes with CACNA1A in lipid raft fractions.

Interleukin-1 receptor-associated kinase-like 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.