Anti-HSD11B1 Konijn Monoklonale Antilichaam

Boster Bio Anti-HSD11B1 Rabbit Monoclonal Antibody catalog # M01565-1. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta;2.7.11.1; MAD3/BUB1-related protein kinase; hBUBR1; Mitotic checkpoint kinase MAD3L; Protein SSK1; BUB1B; BUBR1, MAD3L, SSK1

HSD11B1

3290

P28845

Human, Mouse, Rat

A synthesized peptide derived from human HSD11B1

Clone: 17H86

Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index. .

WB, IHC

Cancer, Cell Biology, Cell Cycle, Cell Division, Epigenetics and Nuclear Signaling, Kinases/Phosphatases, Spindle

Affinity-chromatography

0.5mg/ml

Liquid

Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M01565-1

119545 MW

69 kDa

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and CASC5.

Glycogen synthase kinase-3 beta (gsk3b)

IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.