Anti-HSD17B1 Antibody Picoband® fluoro488 Vervoeging

Estradiol 17-beta-dehydrogenase 1 is an enzyme that in humans is encoded by the HSD17B1 gene. This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants.

Estradiol 17-beta-dehydrogenase 1;1.1.1.62;17-beta-hydroxysteroid dehydrogenase type 1;17-beta-HSD 1;20 alpha-hydroxysteroid dehydrogenase;20-alpha-HSD; E2DH; Placental 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 28C member 1; HSD17B1; E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1

HSD17B1

3292

P14061

Human, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human HSD17B1, different from the related rat and mouse sequences by one amino acid.

Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. .

Flow Cytometry

Cancer, Endocrine System, Energy Metabolism, Energy Transfer Pathways, Growth Factors, Growth Factors/Hormones, Metabolic Signaling Pathways, Metabolism, Neuroscience, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

1. Entrez Gene: HSD17B1 Hydroxysteroid (17-beta) dehydrogenase 1. 2. Aka JA, Mazumdar M, Chen CQ, Poirier D, Lin SX (Apr 2010) . 17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production.Molecular Endocrinology. 24 (4) : 832–45.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

34950 MW

No cross reactivity with other proteins.

6

Estradiol 17-beta-dehydrogenase 1

Cytoplasm.

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Estradiol 17-beta-dehydrogenase 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.