Anti-HSPA2 Antibody Picoband® 31.0550 Vervoeging

HSPA2 (heat shock 70kDa protein 2) also known as HEAT-SHOCK PROTEIN, 70-KD, 2, HSP70-2, HEAT-SHOCK PROTEIN, 70-KD, 3 or HSP70-3. Analysis of the sequence indicated that  HSPA2  is the human homolog of the murine Hsp70-2 gene, with 91.7% identity in the nucleotide coding sequence and 98.2% in the corresponding amino acid sequence.HSPA2  has less amino acid homology to the other members of the human HSP70 gene family.  HSPA2  is constitutively expressed in most tissues, with very high levels in testis and skeletal muscle. The  HSPA2  gene is located on chromosome 14q22-q24. Immunohistochemical analysis detected weak expression of  HSPA2  in spermatocytes and stronger expression in spermatids and in the tail of mature sperm. HSPA2  may be critical to sperm maturation through its role as a protein chaperone.

Heat shock-related 70 kDa protein 2; Heat shock 70 kDa protein 2; HSPA2

HSPA2

3306

P54652

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human HSPA2, identical to the related mouse and rat sequences.

HSPA1B is testis-specific.

Flow Cytometry

Cancer, Chaperones, Heat Shock Proteins, Protein Trafficking, Signal Transduction, Tumor Biomarkers

Immunogen affinity purified.

Liquid

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.

1. Bonnycastle, L. L. C., Yu, C.-E., Hunt, C. R., Trask, B. J., Clancy, K. P., Weber, J. L., Patterson, D., Schellenberg, G. D. Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2) . Genomics 23: 85-93, 1994. 2. Dix, D. J., Allen, J. W., Collins, B. W., Mori, C., Nakamura, N., Poorman-Allen, P., Goulding, E. H., Eddy, E. M. Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proc. Nat. Acad. Sci. 93: 3264-3268, 1996. 3. Hunt, C. R., Gasser, D. L., Chaplin, D. D., Pierce, J. C., Kozak, C. A. Chromosomal localization of five murine HSP70 gene family members: Hsp70-1, Hsp70-2, Hsp70-3, Hsc70t and Grp78. Genomics 16: 193-198, 1993.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

70021 MW

No cross reactivity with other proteins.

6

Heat shock-related 70 kDa protein 2

Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Belongs to the heat shock protein 70 family.

Heat shock-related 70 kDa protein 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.