Anti-Hu CD122 Biotine

CD122 (IL-2/IL-15R beta) constitutes together with CD132 (common gamma chain) and with CD25 (IL-2/IL15R alpha) the intermediate (CD122+CD132) and the high affinity (CD122+CD132+CD25) IL-2 and IL-15 receptor complex. CD122 is expressed on NK cells and lymphocytes, but at low level, unless the cell is activated. The cytoplasmic part of CD122 binds to Src-family and Jak-family kinases. The biological effect of CD122 ligation depends on whether IL-2 or IL-15 is bound to the receptor complex.

Human

TL-Mor cell line

CD122

TU27

FC (QC tested), IP

1 mg/mL

Biotin

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

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Store at 2-8°C. Do not freeze.

The mouse monoclonal antibody TU27 recognizes an extracellular epitope of CD122 (IL-2R beta), a 70-75 kDa type I transmembrane glycoprotein constitutively expressed by NK cells and a T cell subset, and upregulated upon activation.

Flow cytometry: Recommended dilution: 1-5 μg/ml.

Mouse IgG1 kappa