Anti-Hu CD155 APC

CD155 is a type I transmembrane glycoprotein of the nectin family, which serves as an adhesion molecule involved in intercellular and cell-extracellular matrix interactions. CD155 (nectin-like 5) heterodimerizes with CD113 (nectin-3) and this complex binds to CD51/CD61 complex (integrin alphaVbeta3), and to vitronectin. CD155 is also thought to regulate CD44 binding to hyaluronan, and serves as a receptor for poliovirus and cytomegalovirus. It is expressed on endothelial cells, epithelia, central nervous system, and monocytes.

Human

Human neuroblastoma SK-L cells

CD155

SKII.4

FC (QC tested)

APC

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

*Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M: A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. Eur J Immunol. 2009 Mar;39 (3) :695-703., URL: https://www.ncbi.nlm.nih.gov/pubmed/19197944, *Jin HS, Choi DS, Ko M, Kim D, Lee DH, Lee S, Lee AY, Kang SG, Kim SH, Jung Y, Jeong Y, Chung JJ, Park Y: Extracellular pH modulating injectable gel for enhancing immune checkpoint inhibitor therapy. J Control Release. 2019 Oct 25;315:65-75., URL: https://www.ncbi.nlm.nih.gov/pubmed/31669264, *Fionda C, Abruzzese MP, Zingoni A, Soriani A, Ricci B, Molfetta R, Paolini R, Santoni A, Cippitelli M: Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation. BMC Cancer. 2015 Jan 22;15:17., URL: https://www.ncbi.nlm.nih.gov/pubmed/25609078, *Davis ZB, Sowrirajan B, Cogswell A, Ward JP, Planelles V, Barker E: CD155 on HIV-Infected Cells Is Not Modulated by HIV-1 Vpu and Nef but Synergizes with NKG2D Ligands to Trigger NK Cell Lysis of Autologous Primary HIV-Infected Cells. AIDS Res Hum Retroviruses. 2017 Feb;33 (2) :93-100., URL: https://www.ncbi.nlm.nih.gov/pubmed/27296670, *Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA: The TIGIT/CD226 axis regulates human T cell function. J Immunol. 2012 Apr 15;188 (8) :3869-75, URL: https://www.ncbi.nlm.nih.gov/pubmed/22427644, *Josefsson SE, Beiske K, Blaker YN, Førsund MS, Holte H, Østenstad B, Kimby E, Köksal H, Wälchli S, Bai B, Smeland EB, Levy R, Kolstad A, Huse K, Myklebust JH: TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma. Cancer Immunol Res. 2019 Mar;7 (3) :355-362. , URL: https://www.ncbi.nlm.nih.gov/pubmed/30659053, *Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M: Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155) . J Immunol. 2004 Apr 1;172 (7) :3994-8. , URL: https://www.ncbi.nlm.nih.gov/pubmed/15034010

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

The mouse monoclonal antibody SKII.4 recognizes an extracellular epitope of CD155, a transmembrane glycoprotein, known as poliovirus and cytomegalovirus receptor.

6

Mouse IgG1