Anti-Hydroxysteroïde (17-beta) Dehydrogenase 4/HSD17B4 Antibody Picoband® fluoro488 Vervoeging

Peroxisomal multifunctional enzyme type 2 is a protein that in humans is encoded by the HSD17B4 gene. The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD) . An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Peroxisomal multifunctional enzyme type 2; MFE-2;17-beta-hydroxysteroid dehydrogenase 4;17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MPF-2; Short chain dehydrogenase/reductase family 8C member 1; (3R) -hydroxyacyl-CoA dehydrogenase;1.1.1.n12; Enoyl-CoA hydratase 2;4.2.1.107;4.2.1.119;3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; HSD17B4; EDH17B4, SDR8C1

HSD17B4

3295

F5HE57

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of Hydroxysteroid (17-beta) Dehydrogenase 4, identical to the related rat and mouse sequences.

Present in many tissues with highest concentrations in liver, heart, prostate and testis.

Flow Cytometry

Cardiovascular, Fatty Acid Oxidation, Fatty Acids, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Redox Metabolism, Signal Transduction, Tumor Biomarkers

Immunogen affinity purified.

Liquid

Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids. .

1. Entrez Gene: HSD17B4 Hydroxysteroid (17-beta) dehydrogenase 1. 2. Aka JA, Mazumdar M, Chen CQ, Poirier D, Lin SX (Apr 2010) . 17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production.Molecular Endocrinology. 24 (4) : 832–45.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

79686 MW

No cross reactivity with other proteins.

6

Peroxisomal multifunctional enzyme type 2

Peroxisome.

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Peroxisomal multifunctional enzyme type 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.