Anti-I-309/CCL1 Antibody Picoband® fluoro550 Vervoeging

CCL1, Chemokine (C-C motif) ligand 1, is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine receptor CCR8.

C-C motif chemokine 1; Small-inducible cytokine A1; T lymphocyte-secreted protein I-309; CCL1; SCYA1

CCL1

6346

P22362

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human I-309.

Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.

Flow Cytometry

Chemokines, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. .

1. Miller, M. D., Wilson, S. D., Dorf, M. E., Seuanez, H. N., O'Brien, S. J., Krangel, M. S.Sequence and chromosomal location of the I-309 gene: relationship to genes encoding a family of inflammatory cytokines.J. Immun. 145: 2737-2744, 1990.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

10992 MW

No cross reactivity with other proteins.

6

C-C motif chemokine 1

Secreted.

Belongs to the intercrine beta (chemokine CC) family.

C-C motif chemokine 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.