Anti-IFIT5 Antibody Picoband® 31.0550 Vervoeging

IFIT5, also named as Interferon-induced 58 kDa protein or RI58, is a 482 amino acid protein, which contains eight TPR repeats and belongs to the IFIT family. IFIT5 localizes in the Cell projection. Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs.

BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5; BAG5; KIAA0873

IFIT5

24138

Q13325

Human

No cross-reactivity with other proteins.

E.coli-derived human IFIT5 recombinant protein (Position: N23-S439) .

Expressed in all tissues examined with lower levels in brain and testis.

Flow Cytometry

Interleukins

Immunogen affinity purified.

Liquid

Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity) . May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. .

1. Abbas, Y. M., Pichlmair, A., Gorna, M. W., Superti-Furga, G., Nagar, B. Structural basis for viral 5-prime-PPP-RNA recognition by human IFIT proteins. Nature 494: 60-64, 2013. 2. Feng, F., Yuan, L., Wang, Y. E., Crowley, C., Lv, Z., Li, J., Liu, Y., Cheng, G., Zeng, S., Liang, H. Crystal structure and nucleotide selectivity of human IFIT5/ISG58. (Letter) Cell Res. 23: 1055-1058, 2013. 3. Gross, M. B. Personal Communication. Baltimore, Md. 12/18/2014.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

51200 MW

6

BAG family molecular chaperone regulator 5

Perinuclear region.

BAG family molecular chaperone regulator 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.