Anti-IFITM1 Antibody Picoband® fluoro550 Vervoeging

Interferon-induced Transmembrane Protein 1 (IFITM1), also called Interferon-induced Protein 17 (IFI17) . IFITM1 activity is required for primordial germ cells (PGCs) transit from the mesoderm into the endoderm, and that it appears to act via a repulsive mechanism, such that PGCs avoid Ifitm1-expressing tissues. It is mapped to Chr.11 and belongs to the family of interferon-induced transmembrane proteins (Ifitm/mil/fragilis), which encodes cell surface proteins that may modulate cell adhesion and influence cell differentiation. Interferon-inducible membrane proteins of approximately 17 kDa have been suggested to play a role in the antiproliferative activity of interferons based on their pattern of induction in interferon-sensitive and -resistant cell lines and the ability of a membrane fraction enriched in 17-kDa proteins to inhibit cell growth.

Interferon-induced transmembrane protein 1; Dispanin subfamily A member 2a; DSPA2a; Interferon-induced protein 17; Interferon-inducible protein 9-27; Leu-13 antigen; CD225; IFITM1; CD225, IFI17

IFITM1

8519

P13164

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human IFITM1.

Bone (at protein level) . Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines. .

Flow Cytometry

Adapters, Cancer, Cytokines, Immunology, Innate Immunity, Interferons, Oncoproteins/Suppressors, p53 Pathway, Signal Transduction, Signaling Pathways, Stem Cells, Surface Molecules, TGF Beta, Transmembrane, Tumor Biomarkers, Tumor Suppressors

Immunogen affinity purified.

Liquid

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) . Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. .

1. Tanaka, S. S.; Yamaguchi, Y. L.; Tsoi, B.; Lickert, H.; Tam, P. P. L. : IFITM/Mil/Fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Dev. Cell 9: 745-756, 2005. 2. Deblandre, G. A.; Marinx, O. P.; Evans. S. S.; Majjaj, S.; Leo, O.; Caput, D.; Huez, G. A.; Wathelet, M. G. : Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. J. Biol. Chem. 270: 23860-23866, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

13964 MW

No cross reactivity with other proteins.

6

Interferon-induced transmembrane protein 1

Cell membrane ; Single-pass membrane protein .

Belongs to the intermediate filament family.

Interferon-induced transmembrane protein 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.