Anti-IKAP ELP1 Antilichaam

IKAP was initially identified as a scaffold protein of the IκB kinase complex that could bind to IKKα , IKKβ , NF-κB, and the NF-κB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD) . Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD.

Boster Bio Anti-IKAP ELP1 Antibody (Catalog # A31687) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.

FD, DYS, ELP1, IKAP, IKI3, TOT1, Elongator complex protein 1, IkappaB kinase complex-associated protein

IKBKAP

O95163

Human, Mouse

At least two isoforms of IKAP are known two exist, this antibody will detect both isoforms.

IKAP antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human IKAP. The immunogen is located within the last 50 amino acids of IKAP.

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

ELISA, WB, ICC, IF

Signal Transduction

IKAP Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) .

IKAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A31687

150254 MW

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

Cytoplasm

Rabbit, Rat

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

IgG

IKAP Antibody is supplied in PBS containing 0.02% sodium azide.