Anti-IL-10/IL10 Antilichaam 31.0550 Vervoeging

Interleukin-10 (IL-10 or IL10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells.IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. Kim et al. (1992) showed that the mouse Il 10 gene contains 5 exons and spans about 5.2 kb of genomic DNA. Eskdale et al. (1997) mapped the IL10 gene to the junction between 1q31 and 1q32.

Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF; IL10

IL10

3586

P22301

Human

No cross-reactivity with other proteins.

E.coli-derived human IL-10/IL10 recombinant protein (Position: K137-N178) .

Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.

Flow Cytometry

Adaptive Immunity, Cancer, Cytokines, Immunology, Innate Immunity, Interleukins, Tumor Immunology

Immunogen affinity purified.

Liquid

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

1. Eskdale J, Kube D, Tesch H, Gallagher G (1997) . Mapping of the human IL10 gene and further characterization of the 5' flanking sequence.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24993 MW

6

Interleukin 10

Secreted.

Receptor tyrosine-protein kinase erbB-2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.