Anti-IL-17A/II17a Antilichaam 31.0647 Vervoeging

Interleukin-17A is a protein that in humans is encoded by the IL17A gene. The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO) . High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8; Il17a; Ctla8; Il17

Il17a

301289

Q61453

Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived rat IL-17A/Il17a recombinant protein (Position: A18-S150) .

Restricted to a subset of activated T-cells.

Flow Cytometry

Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation

Immunogen affinity purified.

Liquid

Ligand for IL17RA (PubMed:17911633) . The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (By similarity) . Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (By similarity) .

1. Entrez Gene: IL17A interleukin 17A. 2. Rouvier E, Luciani MF, Mattéi MG, Denizot F, Golstein P (June 1993) . CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. Journal of Immunology. 150 (12) : 5445–56.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Interleukin 17A

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.