Anti-IL17/IL17A Antilichaam Picoband® fluoro594 Vervoeging

Interleukin-17A is a protein that in humans is encoded by the IL17A gene. The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO) . High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8; Il17a; Ctla8, Il17

IL17A

16171

Q62386

Mouse

No cross-reactivity with other proteins

E. coli-derived mouse IL-17 recombinant protein (Position: A26-A158) .

Restricted to a subset of activated T-cells. .

Flow Cytometry

Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation

Immunogen affinity purified.

Liquid

Induces stromal cells to produce proinflammatory and hematopoietic cytokines. .

1. Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., Weaver, C. T.Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.Nature Immun. 6: 1123-1132, 2005. 2. Kennedy, J., Rossi, D. L., Zurawski, S. M., Vega, F., Jr.Kastelein, R. A.; Wagner, J. L.; Hannum, C. H.; Zlotnick, A.: Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells.J. Interferon Cytokine Res. 16: 611-617, 1996. 3. Kotake, S., Udagawa, N., Takahashi, N., Matsuzaki, K., Itoh, K., Ishiyama, S., Saito, S., Inoue, K., Kamatani, N., Gillespie, M. T., Martin, T. J., Suda, T.IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.J. Clin. Invest. 103: 1345-1352, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

17490 MW

No cross reactivity with other proteins.

6

Interleukin-17A

Secreted.

Belongs to the immunoglobulin superfamily. CEA family.

Interleukin-17A (IL-17/IL-17A)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.