Anti-IL2 Receptor beta/IL2RB Antilichaam Picoband® 31.0647 Vervoeging

IL2RB (INTERLEUKIN 2 RECEPTOR, BETA), also called CD122, is a protein that in humans is encoded by the IL2RB gene. The gene represents the beta subunit and is a type I membrane protein. IL2RB is mapped to 22q12.3. The IL2RB gene contains 10 exons spanning about 24.3 kb and that the gene product is encoded by exons 2-10. The IL2 receptor is present in 3 forms with respect to binding ability to IL2: high, intermediate, and low affinity forms. Analysis of mutants of the beta chain of the IL2 receptor reveals that the granulocyte and monocyte differentiation signals are triggered by different cytoplasmic domains, showing that the signaling pathways responsible for these unique developmental outcomes are separable.

Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; p70-75; p75; CD122; IL2RB

IL2RB

3560

P14784

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human IL2RB.

Flow Cytometry

Adaptive Immunity, Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Interleukins, Lymphoid, Myeloid, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Stem Cells, Tyrosine Kinases

Immunogen affinity purified.

Liquid

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

1. Campbell, H. D., Webb, G. C., Kono, T., Taniguchi, T., Ford, J. H., Young, I. G. Assignment of the interleukin-2 receptor beta chain gene (Il-2rb) to band E on mouse chromosome 15. Genomics 12: 179-180, 1992. 2. Dai, H., Wan, N., Zhang, S., Moore, Y., Wan, F., Dai, Z. Cutting edge: programmed death-1 defines CD8+CD122+ T cells as regulatory versus memory T cells. J. Immun. 185: 803-807, 2010. 3. Yamashita, Yuki; Kojima Katsuhiko, Tsukahara Tomonori, Agawa Hideyuki, Yamada Koichiro, Amano Yuji, Kurotori Naoki, Tanaka Nobuyuki, Sugamura Kazuo, Takeshita Toshikazu (May. 2008) . Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain. J. Cell. Sci. (England) 121 (Pt 10) : 1727–38. doi:10.1242/jcs.024455.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

61117 MW

No cross reactivity with other proteins.

6

Interleukin-2 receptor subunit beta

Membrane; Single-pass type I membrane protein.

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta/IL-2R subunit beta/IL-2RB)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.