Anti-IL2 receptor gamma/IL2RG Antilichaam Picoband® 31.0550 Vervoeging

IL2RG (INTERLEUKIN 2 RECEPTOR, GAMMA), also known as Common gamma chain or CD132, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors:IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. IL2RG is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. By fluorescence in situ hybridization and PCR amplification of somatic cell hybrid DNAs, The IL2RG gene is mapped to Xq13.1. The IL2RG gene contains 8 exons and spans approximately 4.2 kb. And the gamma chain is an indispensable component of the functional IL2 receptor. Lymphocytes expressing the common gamma chain can form functional receptors for these cytokine proteins, which transmit signals from one cell to another and programs of cellular differentiation. The sharing of the gamma subunit by several receptors explains why humans and mice that lack IL2 entirely show milder symptoms than those with IL2RG deficiency.

Cytokine receptor common subunit gamma; Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC; p64; CD132; IL2RG

IL2RG

3561

P31785

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human IL2 Receptor gamma.

Flow Cytometry

Cancer, Cell Type Markers, Cytokines, Immunology, Innate Immunity, Interleukins, Tumor Immunology

Immunogen affinity purified.

Liquid

Common subunit for the receptors for a variety of interleukins.

1. Asao, H., Okuyama, C., Kumaki, S., Ishii, N., Tsuchiya, S., Foster, D., Sugamura, K. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J. Immun. 167: 1-5, 2001. 2. Brandt, K., Singh, P. B., Bulfone-Paus, S., Ruckert, R. Interleukin-21: a new modulator of immunity, infection, and cancer. Cytokine Growth Factor Rev. 18: 223-232, 2007. 3. PDB 2B5IWang X, Rickert M, Garcia KC (November 2005) . Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science 310 (5751) : 1159–63. doi:10.1126/science.1117893. PMID 16293754.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

42287 MW

No cross reactivity with other proteins.

6

Cytokine receptor common subunit gamma

Membrane; Single-pass type I membrane protein.

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Cytokine receptor common subunit gamma

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.