Anti-IL21R Antibody Picoband® 0,00647 Vervoeging

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21) . It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

IL21R; NILR; UNQ3121/PRO10273; Interleukin-21 receptor; IL-21 receptor; IL-21R; Novel interleukin receptor; CD antigen CD360

IL21R

50615

Q9HBE5

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human IL21R. Human IL21R shares 78.6% amino acid (aa) sequence identity with mouse IL21R.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Asao, H., Okuyama, C., Kumaki, S., Ishii, N., Tsuchiya, S., Foster, D., Sugamura, K. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J. Immun. 167: 1-5, 2001. 2. Barnett, B. E., Ciocca, M. L., Goenka, R., Barnett, L. G., Wu, J., Laufer, T. M., Burkhardt, J. K., Cancro, M. P., Reiner, S. L. Asymmetric B cell division in the germinal center reaction. Science 335: 342-344, 2012. 3. Elsaesser, H., Sauer, K., Brooks, D. G. IL-21 is required to control chronic viral infection. Science 324: 1569-1572, 2009. Note: Erratum: Science 325: 946 only, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

59 kDa

6

Interleukin 21 receptor

Interleukin-21 receptor

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.