Anti-IL34 Antibody Picoband® 31.0550 Vervoeging

Interleukin 34 (IL-34) is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening of secreted proteins; chimpanzee, murine, rat and chicken interleukin 34 orthologs have also been found. The protein is composed of 241 amino acids, 39 kilodaltons in mass, and forms homodimers. IL-34 increases growth or survival of immune cells known as monocytes; it elicits its activity by binding the Colony stimulating factor 1 receptor. This gene is mapped to 16q22.1.

Interleukin-34; IL-34; IL34; C16orf77

IL34

146433

Q6ZMJ4

Human

No cross-reactivity with other proteins.

E.coli-derived human IL34 recombinant protein (Position: N21-R48) .

Detected in the sinusoidal epithelium in the red pulp of spleen. Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.

Flow Cytometry

Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation

Immunogen affinity purified.

Liquid

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

1. Gross, M. B. Personal Communication. Baltimore, Md. 5/30/2014. 2. Lin, H., Lee, E., Hestir, K., Leo, C., Huang, M., Bosch, E., Halenbeck, R., Wu, G., Zhou, A., Behrens, D., Hollenbaugh, D., Linnemann, T., Qin, M., Wong, J., Chu, K., Doberstein, S. K., Williams, L. T. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science 320: 807-811, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

87148 MW

6

Interleukin 34

Secreted.

ADAM metallopeptidase domain 28

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.