Anti-IL3RA Antibody Picoband® fluoro488 Vervoeging

IL3RA (INTERLEUKIN 3 RECEPTOR, ALPHA), also called CD123 (Cluster of Differentiation 123), is a human gene. The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor which is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5) . The IL3RA is mapped on Xp22.33. The genomic structures of IL3RA and CSF2RA are very similar and share an additional exon encoding part of the C-terminal domain not found in other members of this gene family. As in human hematopoietic cells, IL3 and GMCSF competed for binding in fibroblasts expressing the cDNAs for IL3RA, CSF2RA, and the common beta subunit, indicating that different alpha subunits compete for a common beta subunit.

Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123; IL3RA; IL3R

IL3RA

3563

P26951

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human IL3RA.

Flow Cytometry

Adapters, Cytokines, Immunology, Innate Immunity, Interleukins, Signal Transduction, Transmembrane

Immunogen affinity purified.

Liquid

This is a receptor for interleukin-3.

1. Itoh, N., Yonehara, S., Schreurs, J., Gorman, D. M., Maruyama, K., Ishii, A., Yahara, I., Arai, K., Miyajima, A. Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science 247: 324-327, 1990. 2. Kitamura, T., Sato, N., Arai, K., Miyajima, A. Expression cloning of the human IL-3 receptor cDNA reveals a shared beta-subunit for the human IL-3 and GM-CSF receptors. Cell 66: 1165-1174, 1991.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

43330 MW

No cross reactivity with other proteins.

6

Interleukin-3 receptor subunit alpha

Membrane; Single-pass type I membrane protein.

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha/IL-3R subunit alpha/IL-3R-alpha/IL-3RA)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.