Anti-IL5RA Antibody Picoband® 31.0550 Vervoeging

IL5RA (INTERLEUKIN 5 RECEPTOR, ALPHA), also known as CD125, is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene. The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor which is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5) . The IL5RA gene is mapped to 3p26-p24 by Southern blot analysis of DNA from a panel of mouse-human hybrid somatic cell lines complemented by in situ hybridization. And its Cytogenetic location is 3p26.2. Within this 15-residue stretch of IL5RA, the C-terminal phenylalanine is critical. The binding of this protein to IL5 depends on the beta subunit which is activated by the ligand binding and is required for the biological activities of IL5.

Interleukin-5 receptor subunit alpha; IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA; CDw125; CD125; IL5RA; IL5R

IL5RA

3568

Q01344

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human IL5RA.

Expressed on eosinophils and basophils.

Flow Cytometry

Cytokines, Immunology, Innate Immunity, Interleukins

Immunogen affinity purified.

Liquid

This is the receptor for interleukin-5. The alpha chain binds to IL5.

1. Cen, Osman; Gorska Magdalena M, Stafford Susan J, Sur Sanjiv, Alam Rafeul (Mar. 2003) . Identification of UNC119 as a novel activator of SRC-type tyrosine kinases. 2. Geijsen, N., Uings, I. J., Pals, C., Armstrong, J., McKinnon, M., Raaijmakers, J. A. M., Lammers, J.-W. J., Koenderman, L., Coffer, P. J. Cytokine-specific transcriptional regulation through an IL-5R-alpha interacting protein. Science 293: 1136-1138, 2001. 3. Gough, N. M., Rakar, S. Localization of the IL-5 receptor gene to the distal half of murine chromosome 6 using recombinant inbred strains of mice. Genomics 12: 855-856, 1992.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

47685 MW

No cross reactivity with other proteins.

6

Interleukin-5 receptor subunit alpha

Membrane; Single-pass type I membrane protein.

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha/IL-5R subunit alpha/IL-5R-alpha/IL-5RA)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.