Anti-IL6 Antibody Picoband® fluoro488 Vervoeging

Interleukin-6 (IL-6) is a protein that in humans is encoded by the IL6 gene. IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is one of the most important mediators of fever and of the acute phase response. IL-6 is also essential for hybridoma growth and is found in many supplemental cloning media such as briclone. Bowcock et al. (1988) assigned the IL6 gene to chromosome 7p21. By in situ hybridization and Southern blot analysis of mouse-human hybrid cell lines, Sutherland et al. (1988) mapped the IL-6 gene to chromosome 7p15.

Interleukin-6; IL-6; B-cell hybridoma growth factor; Interleukin HP-1; Il6; Il-6

IL6

16193

P08505

Mouse

No cross-reactivity with other proteins

E.coli-derived mouse IL-6 recombinant protein (Position: F25-T211) . Mouse IL-6 shares 40% and 85% amino acid (aa) sequences identity with human and rat IL-6, respectively.

Widely distributed in various tissues.

Flow Cytometry

Innate Immunity, Interleukins, Invasion/Microenvironment, Metabolism, Neurology Process, Neuroscience, Obesity, Tumor Immunology

Immunogen affinity purified.

Liquid

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T (H) 17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. .

1. Ferguson-Smith AC, Chen YF, Newman MS, May LT, Sehgal PB, Ruddle FH (April 1988) . Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24384 MW

No cross reactivity with other proteins.

6

Interleukin-6

Secreted.

Belongs to the actin-binding proteins ADF family.

Interleukin-6

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.