Anti-IMPI/IGF2BP1 Antibody Picoband® fluoro488 Vervoeging

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene. This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.

Bifunctional epoxide hydrolase 2; Cytosolic epoxide hydrolase 2; CEH;3.3.2.10; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Lipid-phosphate phosphatase;3.1.3.76; EPHX2

IGF2BP1

10642

Q9NZI8

Human

No cross-reactivity with other proteins.

E.coli-derived human IMPI/IGF2BP1 recombinant protein (Position: N8-Q562) .

Ubiquitous. A high level expression is seen in secretory tissues.

Flow Cytometry

Cancer Metabolism, Cardiovascular, Cell Biology, Cholesterol Metabolism, Drug Metabolism, Fatty Acid Oxidation, Fatty Acids, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Redox Metabolism, Signal Transduction, Vasculature

Immunogen affinity purified.

Liquid

Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo- 9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro- 9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy- octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate. .

1. Doyle, G. A., Bourdeau-Heller, J. M., Coulthard, S., Meisner, L. F., Ross, J. Amplification in human breast cancer of a gene encoding a c-myc mRNA-binding protein. Cancer Res. 60: 2756-2759, 2000. 2. Hosono, Y., Niknafs, Y. S., Prensner, J. R., Iyer, M. K., Dhanasekaran, S. M., Mehra, R., Pitchiaya, S., Tien, J., Escara-Wilke, J., Poliakov, A., Chu, S.-C., Saleh, S., and 13 others. Oncogenic role of THOR, a conserved cancer/testis long non-coding RNA. Cell 171: 1559-1572, 2017. 3. Huttelmaier, S., Zenklusen, D., Lederer, M., Dictenberg, J., Lorenz, M., Meng, X., Bassell, G. J., Condeelis, J., Singer, R. H. Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1. Nature 438: 512-515, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

62616 MW

6

Bifunctional epoxide hydrolase 2

Cytoplasm. Peroxisome.

Bifunctional epoxide hydrolase 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.