Anti-Importin subunit alfa-6 KPNA5 Antilichaam

Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA5 belongs to a subfamily within the KPNA family that also includes KPNA4 and 6 and is thought to be involved in NLS-dependent protein import into the nucleus.

Boster Bio Anti-Importin subunit alpha-6 KPNA5 Antibody (Catalog # A09441) . Tested in ELISA, IHC-P applications. This antibody reacts with Human.

SRP6, IPOA6, Importin subunit alpha-6, Karyopherin subunit alpha-5

KPNA5

O15131

Human

KPNA5 antibody is human specific. KPNA5 antibody is predicted to not cross-react with other Importin alpha family members.

KPNA5 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human KPNA5. The immunogen is located within amino acids 30 - 80 of KPNA5.

Testis.

ELISA, IHC-P

Homeostasis

KPNA5 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non- classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

KPNA5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A09441

60349 MW

Karyopherin alpha 5 (importin alpha 6)

Cytoplasm.

Rat

Karyopherin alpha 5 (importin alpha 6)

IgG

KPNA5 Antibody is supplied in PBS containing 0.02% sodium azide.