Anti-importine-9 IPO9 Antilichaam

Boster Bio Anti-Importin-9 IPO9 Antibody (Catalog# A10216) . Tested in IHC, WB application (s) . This antibody reacts with Mouse, Human.

Importin-9; Imp9; Ran-binding protein 9; RanBP9; IPO9; IMP9, KIAA1192, RANBP9; HSPC273

IPO9

Q96P70

Mouse, Human

A partial length recombinant Importin-9 protein (amino acids 740-1,041)

IHC, WB

Cell Biology, Cell Cycle, Cell Division, Chromosome Structure, Epigenetics and Nuclear Signaling, Nuclear Import/Export, Nuclear Receptors, Nuclear Signaling Pathways, Protein Trafficking, Signal Transduction

Protein A Chromatography

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Liquid

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity) . Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6. .

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

https://www.bosterbio.com/msds?sku=A10216

115963 MW

Importin-9

Cytoplasm. Nucleus.

Importin-9

Rabbit IgG

100 μ g in 200 μ l PBS containing 0.05% BSA and 0.05% sodium azide.