Anti-INF2 Antibody Picoband®

Inverted formin-2 is a protein that in humans is encoded by the INF2 gene. This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.

Boster Bio Anti-INF2 Antibody Picoband® catalog # A02710-1. Tested in ELISA, Flow Cytometry, IP, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Short transient receptor potential channel 5; TrpC5; Transient receptor protein 5; TRP-5; hTRP-5; hTRP5; TRPC5; TRP5

INF2

64423

Q27J81

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human INF2 recombinant protein (Position: A7-Q674) .

Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.

ELISA, Flow Cytometry, IP, IF, ICC, WB

Calcium Channels, Calcium Signaling, Metabolism, Neuroscience, Neurotransmission, Plasma Membrane, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.

1. Bindschadler, M., McGrath, J. L. Formin' new ideas about actin filament generation. Proc. Nat. Acad. Sci. 101: 14685-14686, 2004. 2. Boyer, O., Nevo, F., Plaisier, E., Funalot, B., Gribouval, O., Benoit, G., Cong, E. H., Arrondel, C., Tete, M.-J., Montjean, R., Richard, L., Karras, A., and 21 others. INF2 mutations in Charcot-Marie-Tooth disease with glomerulopathy. New Eng. J. Med. 365: 2377-2388, 2011. 3. Brown, E. J., Schlondorff, J. S., Becker, D. J., Tsukaguchi, H., Uscinski, A. L., Higgs, H. N., Henderson, J. M., Pollak, M. R., Tonna, S. J. Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Nature Genet. 42: 72-76, 2010. Note: Erratum: Nature Genet. 42: 361 only, 2010.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A02710-1

91791 MW

180 kDa

6

Transient receptor potential cation channel subfamily C member 5

Cell membrane. Multi-pass membrane protein.

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.