Anti-influenzamiddel 10

Anti-Influenza agent 10 (Compound 41) is an influenza A virus RNA-dependent RNA polymerase (RdRp) inhibitor. Anti-Influenza agent 10 exhibits potent antiviral activity against A/PR/8/34 (H1N1) with an IC50 of 0.29μM and a KD of 4.11 μM. Anti-Influenza agent 10 can inhibit the assembly of the viral RdRp complex by disrupting the protein interaction between PA and PB1 subunits, thereby blocking the transcription and replication of the viral genome. Anti-Influenza agent 10 shows significant broad-spectrum effects on multiple influenza virus strains, such as H3N2, H3N8 and H9N2 with IC50 values of 3.96, 1.91 and 1.45 μM. Anti-Influenza agent 10 can be used for the research of influenza A Virus Infection[1].

12352005

DNA/RNA Synthesis; Influenza Virus

Anti-infection; Cell Cycle/DNA Damage

Infection

CC1=CC2=NC(C)=C(N2C=C1SCC(NC3=CC=C(C=C3)Cl)=O)C(NCC4=CC=CC=C4)=O

C25H23ClN4O2S

478.99

[1]Zhang C, et al. Discovery of imidazo[1,2-a]pyridine derivatives as potent anti-influenza agents: SPR affinity-based screening and structure-activity relationship study. Eur J Med Chem. 2026 Feb 5;303:118399.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-180269/

Reference compound1

No Development Reported