Anti-ING3 Antibody Picoband® APC-vervoeging

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.

ING3; HSPC301; Inhibitor of growth protein 3; p47ING3

ING3

54556

Q9NXR8

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human ING3 recombinant protein (Position: M1-Q367) . Human ING3 shares 95.1% and 96.5% amino acid (aa) sequence identity with mouse and rat ING3, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Doyon, Y., Cayrou, C., Ullah, M., Landry, A.-J., Cote, V., Selleck, W., Lane, W. S., Tan, S., Yang, X.-J., Cote, J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Molec. Cell 21: 51-64, 2006. 2. Doyon, Y., Selleck, W., Lane, W. S., Tan, S., Cote, J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Molec. Cell. Biol. 24: 1884-1896, 2004. 3. Gunduz, M., Ouchida, M., Fukushima, K., Ito, S., Jitsumori, Y., Nakashima, T., Nagai, N., Nishizaki, K., Shimizu, K. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. Oncogene 21: 4462-4470, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

47 kDa

6

Inhibitor of growth family member 3

Inhibitor of growth protein 3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.