Anti-Insulin-achtige groeifactor I IGF1 Antibody Picoband® 0,00647 Vervoeging

Insulin-like growth factor 1 (IGF-1) also known as somatomedin C or mechano growth factor is a protein that in humans is encoded by the IGF1 gene. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.Justice et al. (1990) placed the mouse IGF1 gene on chromosome 10.

Insulin-like growth factor I; IGF-I; Mechano growth factor; MGF; Somatomedin-C; IGF1; IBP1

IGF1

3479

P05019

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human IGF-1, different from the mouse and rat sequences by one amino acid.

Detected in brain cortex (at protein level) . Detected in blood platelets. .

Flow Cytometry

Cancer, Developmental Biology, Growth Factors, Growth Factors/Hormones, Signal Transduction

Immunogen affinity purified.

Liquid

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. .

1. Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS (1985) . The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 69 (2) : 157–60. 2. Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL (1983) . Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature 306 (5943) : 609–11.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

21841 MW

No cross reactivity with other proteins.

6

Insulin-like growth factor I

Secreted.

Belongs to the insulin family.

Insulin-like growth factor I (IGF-I)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.