Anti-Integrine β3 (Extracellulair gebied) Antilichaam

Integrins are cell adhesion molecules that can mediate bidirectional transfer of signals across the plasma membrane. The cytoplasmic domains of integrin family members interact with components of the signal transduction apparatus within cells. Integrin receptors contain noncovalently associated α and β subunits that consist of a large extracellular region (the ligand-binding domain), a short transmembrane region, and a cytoplasmic domain of varying length. In mammals, at least 17 α subunits and 8 β subunits have been identified and these proteins can heterodimerize to form at least 22 different receptors. The integrin β2 subunit associates with integrin αL to form a receptor for ICAM family members. Integrin β2/αL is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

Our Integrin β3 (Extracellular region) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat Integrin β3 (Extracellular region) and is protein a purified. It is great for use in ELISA, WB, ICC.

Our Integrin β3 (Extracellular region) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat Integrin β3 (Extracellular region) and is Protein A purified. It is great for use in WB, ICC.

Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61, ITGB3, GP3A

ITGB3

P05106

Human, Mouse, and Rat

Clone M581 was generated from a recombinant protein containing amino acid residues in the extracellular region of human Integrin β3. This sequence has high homology with rat and mouse Integrin β3, and has low homology to other integrin family members.

Integrin β3 (Extracellular region)

M581

Unconjugated

ELISA, WB, ICC

Cell Adhesion Molecules, Cell Signaling, Cytoskeletal Regulation, Oncoproteins

Protein A Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

100

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Protein A purified culture supernatant.

1:500

This antibody detects a 100kDa* protein corresponding to the molecular mass of Integrin β3 on SDS-PAGE immunoblots of human platelets and endothelial cells (HUVEC) .

1:50

Western blots performed on each lot.

Mouse

Liquid

IgG1

Human

Quality Control: WB

AB_3068460