Anti-Integrine β4 (Cytoplasmatisch gebied) Antilichaam

The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins. Activation of IκBα occurs through both serine and tyrosine phosphorylation events. Activation through phosphorylation at Ser-32 and Ser-36 is followed by proteasome-mediated degradation, resulting in the release and nuclear translocation of active NF-κB. This pathway of IκBα regulation occurs in response to various NF-κB-activating agents, such as TNFα, interleukins, LPS, and irradiation. An alternative pathway for IκBα regulation occurs through tyrosine phosphorylation of Tyr-42 and Tyr-305. Tyr-42 is phosphorylated in response to oxidative stress and growth factors. This phosphorylation can lead to degradation of IκBα and NF-κB-activation. In contrast, Tyr-305 phosphorylation by c-Abl has been implicated in IκBα nuclear translocation and inhibition of NF-κB-activation. Thus, tyrosine phosphorylation of IκBα may be an important regulatory mechanism in NF-κB signaling.

Our Integrin β4 (Cytoplasmic region) mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Integrin β4 (Cytoplasmic region) and is protein a purified. It is great for use in ELISA, WB, ICC.

Our Integrin β4 (Cytoplasmic region) mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Integrin β4 (Cytoplasmic region) and is Protein A purified. It is great for use in WB, ICC.

Integrin, CD104, GP150

ITGB4

P16144

Human

Clone M126 was generated from a recombinant protein containing amino acid residues in the cytoplasmic region of human Integrin β4. This sequence is found in all three Integrin β4 isoforms and has 90% homology with rat and mouse Integrin β4.

Integrin β4 (Cytoplasmic region)

M126

Unconjugated

ELISA, WB, ICC

Cell Adhesion Molecules, Cell Signaling, Cytoskeletal Regulation, Oncoproteins

Protein A Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

GOmAb

200

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Protein A purified culture supernatant.

1:1000

This antibody detects a 200kDa* protein corresponding to the molecular mass of Integrin β4 on SDS-PAGE immunoblots of human A431 cells.

1:250

Western blots performed on each lot.

Mouse

Liquid

IgG1

Human

Quality Control: WB

AB_2129145