Anti-Integrine alfa 1/ITGA1 Antibody Picoband® fluoro550 Vervoeging

Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.

Integrin alpha-1; CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1; CD49a; ITGA1

ITGA1

3672

P56199

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha 1, different from the related mouse and rat sequences by one amino acid.

Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. .

Flow Cytometry

Cancer, Cell Adhesion, Cytoskeleton/ECM, Integrins, Invasion/Microenvironment, Signal Transduction

Immunogen affinity purified.

Liquid

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. .

1. Douville, P.; Seldin, M. F.; Carbonetto, S. : Genetic mapping of the integrin alpha-1 gene (Vla1) to mouse chromosome 13. Genomics 14: 503-505, 1992. 2. Lee HJ, Kim SY; Koh JM; Bok J; Kim KJ; Kim KS; Park MH; Shin HD; Park BL; Kim TH; Hong JM; Park EK; Kim DJ; Oh B; Kimm K; Kim GS; Lee JY. Polymorphisms and haplotypes of integrinalpha1 (ITGA1) are associated with bone mineral absorbance and fracture risk in postmenopausal Koreans.Bone. 2007 Dec;41 (6) :979-86. Epub 2007 Sep 5. 3. Ekholm, E.; Hankenson, K. D.; Uusitalo, H.; Hiltunen, A.; Gardner, H.; Heino, J.; Penttinen, R. : Diminished callus size and cartilage synthesis in alpha-1 beta-1 integrin-deficient mice during bone fracture healing. Am. J. Path. 160: 1779-1785, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

130848 MW

No cross reactivity with other proteins.

6

Integrin alpha-1

Membrane; Single-pass type I membrane protein.

Belongs to the integrin alpha chain family.

Integrin alpha-1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.