Anti-Integrine-alfa V/ITGAV Antibody Picoband® (monoklonale, 8B10H2)

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. It is a member of the beta 3 integrin subfamily (cytoadhesins) . The human locus for the av gene (VNRA) was previously mapped to the long arm of chromosome 2. Sims et al. (2000) localized the VNRA gene to 2q31. The gene contains 30 exons and spans over 93 kb of genomic DNA. It functions as a receptor for a group of proteins that includes vitronectin, fibrinogen, thrombospondin, and von Willebrand factor.

Lysosomal alpha-glucosidase;3.2.1.20

ITGAV

3685

P06756

Human

No cross-reactivity with other proteins.

E.coli-derived human Integrin alpha V/ITGAV recombinant protein (Position: H732-D970) .

Clone: 8B10H2

Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) . Expressed on neutrophils (at protein level) . Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) .

Flow Cytometry

DNA/RNA, Epigenetics and Nuclear Signaling, RNA Processing

Immunogen affinity purified.

Liquid

Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans.

1. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988) . Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa. J Clin Invest 81 (6) : 1993–8. 2. Fernandez-Ruiz, E., de Villena, F. P.-M., Rodriguez de Cordoba, S., Sanchez-Madrid, F.Regional localization of the human vitronectin receptor alpha-subunit gene (VNRA) to chromosome 2q31-q32.Cytogenet. Cell Genet.62: 26-28, 1993.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Glucosidase alpha, acid

Lysosome

Lysosomal alpha-glucosidase

Mouse IgG2b

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.