Anti-interferon regelgevingsfactor 5 IRF5 Antibody Picoband® fluoro594 Vervoeging

Interferon regulatory factor 5, also called IRF5 or SLEB10, is a protein that in humans is encoded by the IRF5 gene. IRF5 gene is mapped to 7q32.1. This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. This gene is a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection.

Interferon regulatory factor 5; IRF-5; IRF5

IRF5

3663

Q13568

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human IRF5, identical to the related rat sequence, and different from the related mouse sequence by two amino acids.

Expressed predominantly in peripheral blood lymphocytes. .

Flow Cytometry

Cytokines, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Immunology, Innate Immunity, Interferons, Polymerase Associated Factors, Transcription, Transcription Factors

Immunogen affinity purified.

Liquid

Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. .

1. Couzinet, A., Tamura, K., Chen, H., Nishimura, K., Wang, Z., Morishita, Y., Takeda, K., Yagita, H., Yanai, H., Taniguchi, T., Tamura, T. A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis. Proc. Nat. Acad. Sci. 105: 2556-2561, 2008. 2. Sigurdsson, S., Goring, H. H. H., Kristjansdottir, G., Milani, L., Nordmark, G., Sandling, J. K., Eloranta, M.-L., Feng, D., Sangster-Guity, N., Gunnarsson, I., Svenungsson, E., Sturfelt, G., Jonsen, A., Truedsson, L., Barnes, B. J., Alm, G., Ronnblom, L., Syvanen, A.-C. Comprehensive evaluation of the genetic variants of interferon regulatory growth factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus. Hum. Molec. Genet. 17: 872-881, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

56044 MW

No cross reactivity with other proteins.

6

Interferon regulatory factor 5

Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.

Belongs to the IRF family.

Interferon regulatory factor 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.