Anti-IQSEC2 Antibody Picoband® 0,00647 Vervoeging

This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

IQSEC2; KIAA0522; IQ motif and SEC7 domain-containing protein 2

IQSEC2

23096

Q5JU85

Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human IQSEC2 recombinant protein (Position: A122-M1396) . Human IQSEC2 shares 98.2% amino acid (aa) sequence identity with mouse IQSEC2.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. de Vries, B. B. A., Breedveld, G. J., Deelen, W. H., Niermeijer, M. F., Heutink, P., Breuning, M. H. Another family with nonspecific X-linked mental retardation (MRX78) maps to Xp11.4-p11.23. Am. J. Med. Genet. 111: 443-445, 2002. Note: Erratum: Am. J. Med. Genet. 113: 391 only 2002. 2. Filippova, G. N., Cheng, M. K., Moore, J. M., Truong, J.-P., Hu, Y. J., Nguyen, D. K., Tsuchiya, K. D., Disteche, C. M. Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. Dev. Cell 8: 31-42, 2005. 3. Gedeon, A., Kerr, B., Mulley, J., Turner, G. Pericentromeric genes for non-specific X-linked mental retardation (MRX) . Am. J. Med. Genet. 51: 553-564, 1994.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

163 kDa

6

IQ motif and Sec7 domain ArfGEF 2

IQ motif and SEC7 domain-containing protein 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.