Anti-IRAKM/IRAK3 Antibody Picoband® fluoro550 Vervoeging

Interleukin-1 receptor-associated kinase 3, also called IRAK3 or IRAKM is an enzyme that in humans is encoded by the IRAK3 gene. The IRAKM gene consists of 12 exons spanning a region of approximately 60 kb in chromosome 12q14.3. This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma.

Interleukin-1 receptor-associated kinase 3; IRAK-3;2.7.11.1; IL-1 receptor-associated kinase M; IRAK-M; IRAK3

IRAK3

11213

Q9Y616

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human IRAKM.

Expressed predominantly in peripheral blood lymphocytes. .

Flow Cytometry

Cytokines, Immunology, Innate Immunity, Interleukins, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, TLR Signaling

Immunogen affinity purified.

Liquid

Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. .

1. Balaci, L., Spada, M. C., Olla, N., Sole, G., Loddo, L., Anedda, F., Naitza, S., Zuncheddu, M. A., Maschio, A., Altea, D., Uda, M., Pilia, S., and 30 others. IRAK-M is involved in the pathogenesis of early-onset persistent asthma. Am. J. Hum. Genet. 80: 1103-1114, 2007. 2. Deng, J. C., Cheng, G., Newstead, M. W., Zeng, X., Kobayashi, K., Flavell, R. A., Standiford, T. J. Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J. Clin. Invest. 116: 2532-2542, 2006. 3. Kobayashi, K., Hernandez, L. D., Galan, J. E., Janeway, C. A., Jr., Medzhitov, R., Flavell, R. A. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110: 191-202, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

67767 MW

No cross reactivity with other proteins.

6

Interleukin-1 receptor-associated kinase 3

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.

Interleukin-1 receptor-associated kinase 3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.