Anti-ITPK1 Antilichaam

Boster Bio Anti-ITPK1 Antibody (Catalog# A09106) . Tested in WB, ELISA, IHC applications. This antibody reacts with Human, Mouse.

ITPK1; Inositol-tetrakisphosphate 1-kinase; Inositol 1;3,4-trisphosphate 5/6-kinase; Inositol-triphosphate 5/6-kinase; Ins (1,3,4) P (3) 5/6-kinase

ITPK1

Q13572

Human, Mouse

A peptide derived from human ITPK1. Immunogen sequence location: 81-130

Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen.

WB, ELISA, IHC

Calcium Signaling, Signal Transduction, Signaling Pathway

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Liquid

Kinase that can phosphorylate various inositol polyphosphate such as Ins (3,4,5,6) P4 or Ins (1,3,4) P3. Phosphorylates Ins (3,4,5,6) P4 at position 1 to form Ins (1,3,4,5,6) P5. This reaction is thought to have regulatory importance, since Ins (3,4,5,6) P4 is an inhibitor of plasma membrane Ca (2+) -activated Cl (-) channels, while Ins (1,3,4,5,6) P5 is not. Also phosphorylates Ins (1,3,4) P3 on O-5 and O-6 to form Ins (1,3,4,6) P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins (1,3,4,5) P4 and Ins (1,3,4,6) P4 to Ins (1,3,4) P3, and Ins (1,3,4,5,6) P5 to Ins (3,4,5,6) P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins (1,3,4,5) P4 and Ins (1,3,4,6) P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A09106

45621 MW

Inositol-tetrakisphosphate 1-kinase

Rabbit IgG

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.