Anti-JDP2 Antibody Picoband® 0,00647 Vervoeging

Jun dimerization protein 2 (JUNDM2) is a protein that in humans is encoded by the JDP2 gene. Mouse Jdp2 is an inhibitory subunit of the differentiation regulatory factor (DRF) complex. Jdp2 repressed retinoic acid-induced transcription of the Jun gene by recruiting a histone deacetylase-3 -containing complex to the differentiation response element (DRE) of the Jun promoter. Expression of JDP2 was reduced in several human cancers compared with matched normal tissues. Human JDP2 has antitumorigenic properties.

Relaxin receptor 2; G-protein coupled receptor 106; G-protein coupled receptor affecting testicular descent; Leucine-rich repeat-containing G-protein coupled receptor 8; Relaxin family peptide receptor 2; RXFP2; GPR106; GREAT; LGR8

JDP2

122953

Q8WYK2

Human

No cross-reactivity with other proteins.

E.coli-derived human JDP2 recombinant protein (Position: E33-K163) .

Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.

Flow Cytometry

Endocrine System, G Protein Signaling, More Gpcr, Neuroscience, Neurotransmission, Receptors / Channels, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) .

1. Gross, M. B. Personal Communication. Baltimore, Md. 7/23/2013. 2. Heinrich, R., Livne, E., Ben-Izhak, O., Aronheim, A. The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene. J. Biol. Chem. 279: 5708-5715, 2004. 3. Ji, H., Ehrlich, L. I. R., Seita, J., Murakami, P., Doi, A., Lindau, P., Lee, H., Aryee, M. J., Irizarry, R. A., Kim, K., Rossi, D. J., Inlay, M. A., Serwold, T., Karsunky, H., Ho, L., Daley, G. Q., Weissman, I. L., Feinberg, A. P. Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature 467: 338-342, 2010.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

35883 MW

6

Relaxin family peptide receptor 2

Cell membrane; Multi-pass membrane protein.

Annexin A4

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.